Dynamic Modulation of Enzyme Activity by Near-Infrared Light

Engineering near-infrared (NIR) light-sensitive enzymes remains a huge challenge. A photothermal effect-associated method is developed for tailoring the enzymatic activity of enzymes by exposure to NIR light. An ultrasmall platinum nanoparticle was anchored in an enzyme to generate local heating upon NIR irradiation, which enhanced the enzyme activity without increasing bulk temperature. Following NIR irradiation, the enzyme activity was tailored rapidly and reversibly, and was modulated by varying laser power density and irradiation time. Four enzymes were engineered, including glucoamylase, glucose oxidase, catalase, and proteinase K with NIR-light sensitivity, and demonstrated their utility in practical applications such as photolithography and NIR light-responsive antibacterial or anticancer actions. Our investigation suggests that this approach could be broadly used to engineer enzymes with NIR-light sensitivity for many biological applications.     

A note on functional a posteriori estimates for elliptic optimal control problems

In this work, new results on functional type a posteriori estimates for elliptic optimal control problems with control constraints are presented. More precisely, we derive new, sharp, guaranteed, and fully computable lower bounds for the cost functional in addition to the already existing upper bounds. Using both, the lower and the upper bounds, we arrive at two‐sided estimates for the cost functional. We prove that these bounds finally lead to sharp, guaranteed and fully computable upper estimates for the discretization error in the state and the control of the optimal control problem. First numerical tests are presented confirming the efficiency of the a posteriori estimates derived. © 2016 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 33: 403–424, 2017     

Exact controllability of nodal profile for 1‐D first order quasilinear hyperbolic systems with internal controls

For 1‐D first order quasilinear hyperbolic systems without zero eigenvalues, based on the theory of exact boundary controllability of nodal profile, using an extension method, the exact controllability of nodal profile can be realized in a shorter time by means of additional internal controls acting on suitably small space‐time domains. On the other hand, using a perturbation method, the exact controllability of nodal profile for 1‐D first order quasilinear hyperbolic systems with zero eigenvalues can be realized by additional internal controls to the part of equations corresponding to zero eigenvalues. Furthermore, by adding suitable internal controls to all the equations on suitable domains, the exact controllability of nodal profile for systems with zero eigenvalues can be realized in a shorter time.     

带有不确定参数的一类混沌金融系统的广义投影同步

针对带有不确定参数的一类混沌金融系统,提出了实现驱动系统和响应系统广义投影同步的自适应控制策略,并基于Lyapunov稳定性理论给出和验证了广义投影同步稳定性判据.数值仿真验证了控制策略和理论分析的有效性.     

考虑事故风险损失的爆炸物品经济订货批量模型研究

爆炸物品在储存过程中存在发生爆炸事故,从而给人类和环境带来伤害的可能,因此在对爆炸物品进行采购决策时必需考虑由此带来的风险损失.在给出爆炸物品事故风险损失度量方法的基础上,建立了爆炸物品的经济订货批量模型,证明了模型存在唯一最优解,并给出了模型的求解步骤,为相关企业合理制定采购决策提供了理论依据.数字算例分析了事故概率、赔偿标准、单位库存费、单次采购费对最优批量的影响,比较了考虑事故风险损失与否时的最优批量,结果表明,当事故概率或赔偿标准较高时,两者对应的最优批量差异明显.这也说明,当事故概率或赔偿标准达到一定程度时,考虑事故风险损失是十分必要的.     

侵入气体沿井筒的上升规律研究

地层气体侵入井筒后形成气液两相流动体系,气体沿井筒向上滑脱运移,随着所受压力的降低其发展变化过程会很快,如果不及时处理就会演变为井涌、井喷,甚至井喷失控.因此,准确的预测侵入气体沿井筒的上升规律,有助于认识气侵发展过程,同时为现场采取井控措施提供理论依据,有效避免井下复杂事故.基于侵入气体沿井筒运动的力学特性,建立了气体的上升速度模型,模型模拟分析表明:地层渗透率越高、机械钻速越快、单位时间内侵入井筒的气体量越多、气体上升速度越快,井底压力波动越大;施加一定的井口回压可以有效抑制气体的膨胀运移.     

稳健残差控制图的构建及在金融时序中的应用

对于呈现自相关和波动族聚性并存的受控过程,通常采用残差控制图对其进行监控。但异常点的存在会对自相关或波动族聚性模型的拟合产生重要影响,使得基于该模型的残差并非独立同分布导致常规残差控制图监控失效。为解决这类问题,本文提出稳健残差控制图。即建立稳健的ARMA模型解决自相关问题从而得到无自相关的残差序列,用稳健的GARCH模型来构建控制图的上下限。模拟和实证研究表明,本文提出的稳健残差控制图具有很好的抗异常点能力并能更好的对金融时间序列的异常现象进行监控。     

一类金融混沌系统的线性控制模型

针对一类金融混沌系统,建立存款利率线性控制模型、投资需求线性控制模型和综合线性控制模型,运用线性反馈控制的方法调整导致系统产生混沌的参数组合,实现对系统稳定性的有效控制.首先对控制模型进行动力学分析,从理论上分析控制模型的反馈系数的取值范围;然后通过数值模拟证明方法的可行性;最后讨论线性反馈控制对金融危机宏观调控的实际意义.     

Phase II monitoring of changes in mean from high‐dimensional data

The generalized T² chart (GT‐chart), which is composed of the T² statistic based on a small number of principal components and the remaining components, is a popular alternative to the traditional Hotelling's T² control chart. However, the application of the GT‐chart to high‐dimensional data, which are now ubiquitous, encounters difficulties from high dimensionality similar to other multivariate procedures. The sample principal components and their eigenvalues do not consistently estimate the population values, and the GT‐chart relying on them is also inconsistent in estimating the control limits. In this paper, we investigate the effects of high dimensionality on the GT‐chart and then propose a corrected GT‐chart using the recent results of random matrix theory for the spiked covariance model. We numerically show that the corrected GT‐chart exhibits superior performance compared to the existing methods, including the GT‐chart and Hotelling's T² control chart, under various high‐dimensional cases. Finally, we apply the proposed corrected GT‐chart to monitor chemical processes introduced in the literature.     

时滞离散网络模型的动力学分析与同步

复杂网络广泛存在于日常生活,首先,给出几类标准的网络模型;然后,利用稳定性控制方法设计并实现了具有时滞与非时滞耦合的复杂网络模型快速控制;最后,通过构造优化Lyapunov函数,讨论其模型的射影同步问题,得到了系统全局稳定的条件和有效的控制器,以实例数值验证其方法的可行性。